Open sourcing 4,000,000+ cells with Gateway, a human neuroscience dataset

Crownlands is open sourcing the largest single-cell tissue dataset from living patients to ever have been released, by more than threefold.

AI science is being built on many kinds of data: proteins, genomes, cells, clinical records. But the value of these models ultimately comes from how well they predict human biology. The Gateway dataset is a major milestone in giving these AI models and scientists access to human biological data at scale.

This dataset is aimed at advancing longitudinal understanding of human neuron aging and neurodegenerative disease. We are releasing single-cell data collected from people of all ages, with and without Alzheimer’s disease and Parkinson’s disease, the two most common neurodegenerative diseases. These participants enrolled in our IRB-approved clinical studies this past year.

Our Gateway platform enables the collection of living neurons from patients. These cells, olfactory neurons, are included in the released dataset.

To the people who have joined our studies - thank you for the contributions you are making to science.

To the neuroscience community and to the AI science community - we are excited to build with you, and to put human biological data in your hands so that our collective work can produce the greatest possible translational impact.

You can freely access the data in a few ways.

• Use the beta data agent at chat.crownlands.com, which can access the dataset to answer questions and complete research tasks.
• Explore the full dataset on CZ CELLxGENE.
• Read the preprint on bioRxiv (PDF).